Steady state relative bioavailability and pharmacokinetics of oral propranolol in black and white North Americans
✍ Scribed by Melvin Sharoky; Mark Perkal; Robert Turner; L. J. Lesko
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 583 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0142-2782
No coin nor oath required. For personal study only.
✦ Synopsis
The steady state bioavailability and pharmacokinetics of propranolol over two consecutive dosing intervals were investigated in 18 black and 10 white normal volunteers following the administration of 20 mg of a test and reference oral dosage form, respectively, every 6h. There were no differences (p > 0.05) between dosage forms in the mean (n = 28) area under the plasma concentration-time curve (AUC), maximum plasma concentration (CmJ or time to C, , (t-) for propranolol or its active metabolite, 4hydroxypropranolol. However, as a group blacks had lower plasma concentrations of propranolol and Chydroxypropynolol than whites. The mean AUC and C,, for propranolol during the second doxing interval (AUC-2 and Cmx-2, respectively) were significantly (p < 005) lower in blacks, but there were no ethnic differences (p > 0-05) in tMx. The mean AUC and C, , for the Chydroxylated metabolite during both dosing intervals were significantly (p < 0.05) lower in blacks. Mean oral clearances of propranolol, assuming complete absorption, (range: 42.1-54-5 ml mid' kg-') were similar (p > 0.05) in each racial group. There were no substantial changes in heart rate or blood pressure in blacks or whites following propranolol administration. These data suggest that for oral propranolol, blacks have different absorption and disposition characteristics than whites.