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Steady-state plasma and cerebrospinal fluid pharmacokinetics and tolerability of eslicarbazepine acetate and oxcarbazepine in healthy volunteers

✍ Scribed by Teresa Nunes; José Francisco Rocha; Amílcar Falcão; Luis Almeida; Patrício Soares-da-Silva


Book ID
119855159
Publisher
Wiley (Blackwell Publishing)
Year
2012
Tongue
English
Weight
322 KB
Volume
54
Category
Article
ISSN
0013-9580

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After a single oral dose of (R,S)-ibuprofen (1200 mg) to five healthy volunteers, paired plasma and blister fluid concentrations of drug were determined by a stereospecific HPLC assay. A pharmacokinetic model that incorporated blister fluid as a separate peripheral compartment adequately characteriz