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Steady state pharmacokinetics of conventional versus controlled-release carbamazepine in patients with epilepsy

โœ Scribed by J. Bonneton; A. Iliadis; P. Genton; C. Dravet; D. Viallat; E. Mesdjian


Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
592 KB
Volume
14
Category
Article
ISSN
0920-1211

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Two carbamazepine (CBZ) tablet formulations (conventional, CBZ-CO, or controlled release, CBZ-CR) are commonly prescribed in monotherapy or in comedication with phenobarbital (PB) in the treatment of epilepsies. This study compares the pharmacokinetics of CBZ-CO against CBZ-CR in patients with epile

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Carbamazepine (CBZ) is a widely used antiepileptic drug (AED). Recently, a chewable tablet (Tegretol chewtabs) has been formulated. This open substitution study was designed to compare the two formulations with respect to efficacy and tolerability in patients with intractable epilepsy. Thirty patien