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Steady-state pharmacokinetics and pharmacodynamics of imidaprilat, an active metabolite of imidapril, a new angiotensin-converting enzyme inhibitor in spontaneously hypertensive rats

โœ Scribed by Kenta Yamanaka; Nobuaki Takehara; Kazuo Murata; Kiyoshi Banno; Tadashi Sato


Book ID
109388523
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
264 KB
Volume
85
Category
Article
ISSN
0022-3549

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The disposition characteristics of pentopril (the ethyl ester) and its active carboxylic acid metabolite (CGS 13934) were determined in conscious rats after separate intravenous administrations of both compounds. The relationship between plasma concentration and pharmacological effect was also evalu