Steady-state pattern electroretinogram in insulin-dependent diabetics with no or minimal retinopathy
✍ Scribed by Benedetto Falsini; Vittorio Porciatti; Giuseppe Scalia; Salvatore Caputo; Angelo Minnella; Mauro A. S. Leo; Giovanni Ghirlanda
- Publisher
- Springer-Verlag
- Year
- 1989
- Tongue
- English
- Weight
- 385 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0012-4486
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✦ Synopsis
Steady-state pattern electroretinogram (PERG) in response to sinusoidal gratings (1.7 c/deg spatial frequency; 9 x 9 deg field size) temporally modulated (sinusoidally) at 8 Hz were recorded in 40 insulin-dependent diabetics and 28 age-matched normal subjects. Visual acuity was >/20/20 in all 40 patients; 31 (62 eyes) showed no sign of retinopathy and nine (18 eyes) showed a few microaneurysms on fluorescein angiography, Insulin-dependent diabetics showed a significant reduction in the PERG mean amplitude as compared with age-matched control subjects (one-way analysis of variance: p < 0.0001). Significant differences were observed between normals and diabetics without retinopathy (Scheff~ test: p < 0.0001), normals and diabetics with early retinopathy (Scheff~ test: p < 0.0001), no retinopathy and early retinopathy patients (Scheff~ test: p < 0.05). In diabetics without retinopathy multifactorial analysis of variance revealed a significant effect of age of onset of the disease (p < 0.01) and an interaction effect between age of onset and duration (p < 0.001) on PERG amplitude. These results suggest a possible use of the steady-state PERG to detect early macular dysfunction in insulin-dependent diabetics.