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Steady-state methadone blocks cocaine seeking and cocaine-induced gene expression alterations in the rat brain

✍ Scribed by Francesco Leri; Yan Zhou; Benjamin Goddard; AnneMarie Levy; Derek Jacklin; Mary Jeanne Kreek


Book ID
118436963
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
1007 KB
Volume
19
Category
Article
ISSN
0924-977X

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## Abstract Using a mouse brain cDNA microarray consisting of 2688 gene sequences, which include unknown sequences with the empirical possibility of expression in the brain, the effects of repeated toxic doses of intraperitoneal (i.p.) cocaine (40 mg kg^βˆ’1^, 4 days) on the expression profile of the