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Steady-State Kinetics and Dynamics of Morphine in Cancer Patients: Is Sedation Related to the Absorption Rate of Morphine?

✍ Scribed by Lona L Christrup; Per Sjøgren; Niels-Henrik Jensen; Anne-Marie Banning; Karsten Elbæk; Annette K Ersbøll

Book ID
114267534
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
309 KB
Volume
18
Category
Article
ISSN
0885-3924

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Single-dose and steady-state kinetics of
Single-dose and steady-state kinetics of morphine and its metabolites in cancer patients — a comparison of two oral formulations
✍ J. Hasselström; N. Alexander; C. Bringel; J. O. Svensson; J. Säwe 📂 Article 📅 1991 🏛 Springer 🌐 English ⚖ 671 KB

The single-dose and steady state kinetics of morphine given as controlled-release tablets (30 mg every 12 h) and as a solution (15 mg every 6 h) have been compared in 11 cancer patients with chronic pain. The concentrations of morphine, morphine-3-glucuronide (M3G), and morphine-6-glucuronide (M6G)