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Staurosporine-induced morphological changes in the rat osteoblasts.

✍ Scribed by Rong-Sen Yang; Kuo-Shyan Lu; Wen-Mei Fu; Tang-Kue Liu; Shoei-Yn Lin-Shiau

Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
879 KB
Volume
17
Category
Article
ISSN
1065-6995

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✦ Synopsis

Abstract

Treatment of cultured rat osteoblasts with staurosporine caused a rapid outgrowth of long slender cellular processes and the formation of stellate cells. The number of stellate cells increased with higher concentrations of and longer incubation with staurosporine. Scanning electron microscopy (SEM) revealed that the smooth surface of control polygonal cells became ruffled with many long slender cellular processes, thus increasing the cell surface area. Transmission electron microscopy (TEM) of the stellate cells showed a rich accumulation of large lipid droplets in the cytoplasm. Some lipid droplets had coalesced under the cytoplasmic membrane. We suggest that staurosporine has an effect on the differentiation of cultured rat osteoblasts.

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