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Status of p53 phosphorylation and function in sensitive and resistant human cancer models exposed to platinum-based DNA damaging agents

โœ Scribed by Kalpana Mujoo; Masayuki Watanabe; Junichi Nakamura; AbdulR. Khokhar; ZahidH. Siddik


Book ID
106123300
Publisher
Springer-Verlag
Year
2003
Tongue
English
Weight
603 KB
Volume
129
Category
Article
ISSN
1432-1335

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โœ Jocelyn Cรฉraline; Gaรซl Deplanque; Brigitte Duclos; Jean-Marc Limacher; Amor Hajr ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 206 KB ๐Ÿ‘ 2 views

p53 mutations are found in about 70% of human cancers. In order to evaluate the role of these mutations in response to chemotherapeutic agents, it is important to distinguish between p53 response to DNA-damaging agents in normal and in tumour cells. Here, using normal human fibroblasts (NHFs), we sh