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Statistical prediction of the optimal site for thalamotomy in parkinsonian tremor

โœ Scribed by Dr. F. A. Lenz; S. L. Normand; H. C. Kwan; D. Andrews; L. H. Rowland; M. W. Jones; M. Seike; Y. C. Lin; R. R. Tasker; J. O. Dostrovsky; Y. E. Lenz

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
935 KB
Volume
10
Category
Article
ISSN
0885-3185

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โœฆ Synopsis

Stereotactic lesions in the thalamus for treatment of parkinsonian tremor are often made at the location where neurons fire at approximately tremor frequency (tremor cells). Some of these cells show a large amount of activity at tremor frequency and are significantly correlated with electromyographic activity (EMG) during tremor. Our analysis of cellular location identifies a cluster of neurons showing activity characterized both by concentration of power at tremor frequency and by significant correlation with EMG. In a retrospective analysis of results in 15 patients, lesions placed within 2 mm of the center of this cluster were uniformly effective in relieving tremor. Therefore, a small lesion targeting this cluster is effective in treatment of parkinsonian tremor.

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