Handbook of Statistical Genetics (Baldin
โ
Balding, D. J.; Bishop, M.; Cannings, C.
๐
Article
๐
2008
๐
John Wiley & Sons, Ltd
โ 311 KB
๐ 1 views
Hidden Markov models, the expectation-maximization algorithm, and the Gibbs sampler were introduced for biological sequence analysis in early 1990s. Since then the use of formal statistical models and inference procedures has revolutionized the field of computational biology. This chapter reviews th