Statistical issues in clinical trial design
β Scribed by Kenneth R. Hess
- Publisher
- Current Science Inc.
- Year
- 2007
- Tongue
- English
- Weight
- 597 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1523-3790
No coin nor oath required. For personal study only.
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Absolute proof of efficacy can only be given by placebo controlled trials. It is, however, important to classify a drug within the spectrum of existing therapeutic alternatives and, where effective treatment is available, it may be imperative due to ethical considerations to demonstrate that one dru
In clinical trials, appropriate designs are often chosen to address scientific/medical questions of particular interest to the investigator. For a chosen statistical design, however, standard statistical procedures may not be applicable owing to the nature of the design. In this paper we examine sta