Statistical human genetics : methods and
β Robert C Elston; Jaya M Satagopan; Shuying Sun
π Library
π
2012
π Humana Press
π English
β¦ LIBER β¦
π
Statistical Human Genetics: Methods and Protocols
β Scribed by Robert C. Elston (eds.)
- Publisher
- Humana Press
- Year
- 2017
- Tongue
- English
- Leaves
- 685
- Series
- Methods in Molecular Biology 1666
- Edition
- 2
- Category
- Library
β¬ Acquire This Volume
No coin nor oath required. For personal study only.
β¦ Synopsis
The aim of this volume is to make computer programs for analyzing human genetic data more easily accessible to the beginner.Statistical Human Genetics: Methods and Protocols, Second Edition provides updated and new chapters detailing genetic terms, analysis software, and how to interpret the program outputs. Written in the highly successful Methods in Molecular Biology series format, the chapters include introductions to their respective topics, step-by-step instructions, and tips on troubleshooting and avoiding known pitfalls.
The purpose of Statistical Human Genetics: Methods and Protocols, Second Edition is to ensure successful and meaningful results in the fast-growing field of genetic epidemiology.
β¦ Table of Contents
Front Matter ....Pages i-xii
Statistical Genetic Terminology (Robert C. Elston, Jaya Satagopan, Shuying Sun)....Pages 1-9
Identification of Genotype Errors (Jeffery OβConnell, Yin Yao)....Pages 11-23
Detecting Pedigree Relationship Errors (Lei Sun)....Pages 25-44
Identifying Cryptic Relationships (Lei Sun, Apostolos Dimitromanolakis, Wei-Min Chen)....Pages 45-60
Estimating Allele Frequencies (Indra Adrianto, Courtney Montgomery)....Pages 61-81
Testing Departure from Hardy-Weinberg Proportions (Jian Wang, Sanjay Shete)....Pages 83-115
Estimating Disequilibrium Coefficients (Maren Vens, Andreas Ziegler)....Pages 117-132
Detecting Familial Aggregation (Adam C. Naj, Terri H. Beaty)....Pages 133-169
Estimating Heritability from Twin Studies (Katrina L. Grasby, Karin J. H. Verweij, Miriam A. Mosing, Brendan P. Zietsch, Sarah E. Medland)....Pages 171-194
Estimating Heritability from Nuclear Family and Pedigree Data (Murielle Bochud)....Pages 195-210
Correcting for Ascertainment (Warren Ewens, Robert C. Elston)....Pages 211-232
Segregation Analysis Using the Unified Model (Xiangqing Sun)....Pages 233-256
Design Considerations for Genetic Linkage and Association Studies (JΓ©rΓ©mie Nsengimana, D. Timothy Bishop)....Pages 257-281
Model-Based Linkage Analysis of a Quantitative Trait (Yeunjoo E. Song, Sunah Song, Audrey H. Schnell)....Pages 283-310
Model-Based Linkage Analysis of a Binary Trait (Rita M. Cantor)....Pages 311-326
Model-Free Linkage Analysis of a Quantitative Trait (Nathan J. Morris, Catherine M. Stein)....Pages 327-342
Model-Free Linkage Analysis of a Binary Trait (Wei Xu, Jin Ma, Celia M. T. Greenwood, Andrew D. Paterson, Shelley B. Bull)....Pages 343-373
Single Marker Association Analysis for Unrelated Samples (Gang Zheng, Ao Yuan, Qizhai Li, Joseph L. Gastwirth)....Pages 375-389
Single Marker Family-Based Association Analysis Conditional on Parental Information (Ren-Hua Chung, Daniel D. Kinnamon, Eden R. Martin)....Pages 391-407
Single Marker Family-Based Association Analysis Not Conditional on Parental Information (Junghyun Namkung, Sungho Won)....Pages 409-439
Calibrating Population Stratification in Association Analysis (Huaizhen Qin, Xiaofeng Zhu)....Pages 441-453
Cross-Phenotype Association Analysis Using Summary Statistics from GWAS (Xiaoyin Li, Xiaofeng Zhu)....Pages 455-467
Haplotype Inference (Sunah Song, Xin Li, Jing Li)....Pages 469-484
Multi-SNP Haplotype Analysis Methods for Association Analysis (Daniel O. Stram)....Pages 485-504
The Analysis of Ethnic Mixtures (Xiaofeng Zhu, Heming Wang)....Pages 505-525
Detecting Multiethnic Rare Variants (Weiwei Ouyang, Xiaofeng Zhu, Huaizhen Qin)....Pages 527-538
Identifying Gene Interaction Networks (Danica Wiredja, Gurkan Bebek)....Pages 539-556
Structural Equation Modeling (Catherine M. Stein, Nathan J. Morris, NoΓ©mi B. Hall, Nora L. Nock)....Pages 557-580
Mendelian Randomization (Sandeep Grover, Fabiola Del Greco M., Catherine M. Stein, Andreas Ziegler)....Pages 581-628
Preprocessing and Quality Control for Whole-Genome Sequences from the Illumina HiSeq X Platform (Marvin N. Wright, Damian Gola, Andreas Ziegler)....Pages 629-647
Processing and Analyzing Human Microbiome Data (Xuan Zhu, Jian Wang, Cielito Reyes-Gibby, Sanjay Shete)....Pages 649-677
Back Matter ....Pages 679-689
β¦ Subjects
Human Genetics
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