Statistical Genetics of Quantitative Traits: Linkage, Maps, and QTL

✍ Scribed by Rongling Wu, George Casella, Chang-Xing Ma (auth.)

• Publisher: Springer-Verlag New York
• Year: 2007
• Tongue: English
• Leaves: 369
• Series: Statistics for Biology and Health
• Edition: 1
• Category: Library

✦ Synopsis

This book intends to provide geneticists with the tools needed to understand and model the genetic variation for quantitative traits based on genomic data collected in mapping research and equip statisticians with the uniqueness and ideas in relation to the exploration of genetic secrets using their computational skills. This book also intends to attract researchers toward multidisciplinary research and to introduce them to new paradigms in genomic science. In this book, the statistical and computational theories applied to genetic mapping are developed hand in hand and a number of examples displaying the implications of statistical genomics are introduced.

✦ Table of Contents

Front Matter....Pages I-XVI
Basic Genetics....Pages 1-23
Basic Statistics....Pages 25-41
Linkage Analysis and Map Construction....Pages 43-75
A General Model for Linkage Analysis in Controlled Crosses....Pages 77-106
Linkage Analysis with Recombinant Inbred Lines....Pages 107-122
Linkage Analysis for Distorted and Misclassified Markers....Pages 123-143
Special Considerations in Linkage Analysis....Pages 145-170
Marker Analysis of Phenotypes....Pages 171-201
The Structure of QTL Mapping....Pages 203-221
Interval Mapping with Regression Analysis....Pages 223-235
Interval Mapping by Maximum Likelihood Approach....Pages 237-268
Threshold and Precision Analysis....Pages 269-285
Composite QTL Mapping....Pages 287-302
QTL Mapping in Outbred Pedigrees....Pages 303-329
Back Matter....Pages 331-365

✦ Subjects

Animal Genetics and Genomics; Plant Genetics & Genomics; Computational Biology/Bioinformatics; Statistics for Life Sciences, Medicine, Health Sciences; Genetics and Population Dynamics; Biometrics