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Statistical genetics of normal variation in family data for oligogenic diseases

✍ Scribed by Dr. Michael C. Mahaney; Cashell E. Jaquish; Anthony G. Comuzzie

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 301 KB
Volume: 12
Category: Article
ISSN: 0741-0395
DOI: 10.1002/gepi.1370120642

No coin nor oath required. For personal study only.

✦ Synopsis

A quadrivariate quantitative genetic analysis detected significant heritabilities for four simulated quantitative traits (Q1 -Q4) with additive genetic pleiotropy between traits Q1, 42, and 43. Using univariate segregation analysis, we tentatively detected five major loci: one each for 42, 43, and 4 4 and two, at different maxima, for Q 1. Bivariate one-locus segregation analysis identified significant major locus pleiotropy for Q1, Q2, and 4 3 only; and suggested identity between one of Ql's major genes and that for 42, and between the second 41 major gene and that for 43. Patterns of linkage, supportive of inferences from the bivariate segregation analyses, were detected between three candidate genes and the major genes for Ql,Q2 and 44.

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