Sample size estimation is a major component of the design of virtually every experiment in medicine. Prudent use of the available prior information is a crucial element of experimental planning. Most sample size formulae in current use employ this information only in the form of point estimates, eve
Statistical evidence and sample size determination for Bayesian hypothesis testing
β Scribed by Fulvio De Santis
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 363 KB
- Volume
- 124
- Category
- Article
- ISSN
- 0378-3758
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β¦ Synopsis
This paper considers the problem of choosing the sample size for testing hypotheses on the parameters of a model using Bayes factors. Extending the evidential approach outlined in Royall (Statistical Evidence: a Likelihood paradigm. Chapman & Hall, London (1997), J. Amer. Statist. Assoc. 95 (2000) 760) to the Bayesian framework, the predictive criterion proposed for determining the sample size is maximizing the probability of obtaining substantial evidence in favor of the true hypotheses, i.e. minimizing the probabilities of having either misleading or weak evidence. The method is developed for the normal model in several testing problems that arise, for instance, when comparing treatments in clinical trials.
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