Statistical approaches in oncology clinical development: current paradigm and methodological advancement

✍ Scribed by Lahiri, Soumi; Roychoudhury, Satrajit

Publisher: Chapman & Hall/CRC
Year: 2019
Tongue: English
Leaves: 237
Series: Chapman & Hall/CRC biostatistics series
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

Oncology is a rapidly developing area in medical science. A significant investment in terms of costs, resources and time is required for oncology drug development. Understanding of the challenges at all stages is vital for a successful drug launching. The purpose of this book is to provide an overview and practical solutions to some of these challenges which are commonly observed during setting up, conducting and Read more...

Abstract: Oncology is a rapidly developing area in medical science. A significant investment in terms of costs, resources and time is required for oncology drug development. Understanding of the challenges at all stages is vital for a successful drug launching. The purpose of this book is to provide an overview and practical solutions to some of these challenges which are commonly observed during setting up, conducting and reporting of oncology studies. This book will cover a wide variety of topics related to common challenges in cancer clinical trials across different stages of drug development

✦ Table of Contents

Content: Statistical considerations in phase I oncology trials / Simon Wandel and Satrajit Roychoudhury --
Exposure-response analysis in oncology trials / Yi-Lin Chiu and Balakrishna S. Hosmane --
Statistical measures of interaction for evaluating a predictive biomarker / Jaya Satgopan --
Design considerations for phase II oncology clinical trials / Jared C. Foster, Jennifer Le-Rademacher, and Sumithra J. Mandrekar --
Precision medicine and associated challenges / Rajesh Talluri and Sanjay Sathe --
Use of adaptive design in late-stage oncology trials / Satrajit Roychoudhur, Arunava Chakravartty, and Pabak Mukhopadhyay --
Safety monitoring and analysis in oncology trials / Anastasia Ivanova, Qi Jiang, Olga Marchenko, and Richard C. Zink --
Quality of life / Diane Fairclough --
Impact of evolving regulatory pathways on statistical considerations in oncology clinical trials / Rajeshwari Sridhara.

✦ Subjects

Antineoplastic agents;Development;Cancer;Chemotherapy;Clinical trials;Statistical methods;Drugs;Testing

📜 SIMILAR VOLUMES

Statistics in the Social Sciences: Curre

📁 Statistics in the Social Sciences: Current Methodological Developments

✍ Stanislav Kolenikov, Lori A. Thombs, Douglas Steinley 📂 Library 📅 2010 🌐 English

A one-of-a-kind compilation of modern statistical methods designed to support and advance research across the social sciencesStatistics in the Social Sciences: Current Methodological Developments presents new and exciting statistical methodologies to help advance research and data analysis across th

Statistics in the Social Sciences: Curre

📁 Statistics in the Social Sciences: Current Methodological Developments

📂 Library 📅 2010 🌐 English

A one-of-a-kind compilation of modern statistical methods designed to support and advance research across the social sciencesStatistics in the Social Sciences: Current Methodological Developments presents new and exciting statistical methodologies to help advance research and data a

A Handbook Of Spatial Research Paradigms

📁 A Handbook Of Spatial Research Paradigms And Methodologies: Clinical and Comparative Approaches (Handbook of Spatial Research Paradigms & Methodologies)

✍ Nigel Foreman 📂 Library 📅 1998 🏛 Psychology Press 🌐 English

Spatial cognition is a broad field of enquiry, emerging from a wide range of disciplines and incorporating a wide variety of paradigms that have been employed with human and animal subjects. This volume is part of a two- volume handbook reviewing the major paradigms used in each of the contributors'

Palgrave Advances in Peacebuilding: Crit

📁 Palgrave Advances in Peacebuilding: Critical Developments and Approaches

✍ Oliver P. Richmond 📂 Library 📅 2010 🏛 Palgrave Macmillan 🌐 English

The quality of the peace arrived at via liberal peacebuilding approaches has been poor. The related statebuilding praxis has generally been unable to respond to its critics. What is at stake is a recognition of peacebuildings everyday political, social, economic, and cultural dynamics. This indicate

Palgrave Advances in Peacebuilding: Crit

📁 Palgrave Advances in Peacebuilding: Critical Developments and Approaches

✍ Oliver P. Richmond (eds.) 📂 Library 📅 2010 🏛 Palgrave Macmillan UK 🌐 English

The quality of the peace arrived at via liberal peacebuilding approaches has been poor. The related statebuilding praxis has generally been unable to respond to its critics. What is at stake is a recognition of peacebuilding's everyday political, social, economic, and cultural dynamics. This indi

Advanced Statistics in Regulatory Critic

📁 Advanced Statistics in Regulatory Critical Clinical Initiatives

✍ Wei Zhang, Fangrong Yan, Feng Chen, Shein-Chung Chow 📂 Library 📅 2022 🏛 CRC Press/Chapman & Hall 🌐 English

Advanced Statistics in Regulatory Critical Clinical Initiatives is focused on the critical clinical initiatives introduced by the 21st Century Cure Act passed by the United States Congress in December 2016. The book covers everything from the outline of the initiatives to analy