✦ LIBER ✦
Statistical analysis of log-dose response bioassay experiments with unequal dose ratios for the standard and unknown preparations
✍ Scribed by C. Philip Cox
- Publisher
- John Wiley and Sons
- Year
- 1967
- Tongue
- English
- Weight
- 436 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
Permanganate oxidation of the metabolite of MTX yields a simple pteridine with the properties of 2,4-diamino-7-hydroxy-6-pteridinecarboxylic acid.
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Heating of the latter compound in 2 N sodium hydroxide solution at 70" leads t o slow hydrolysis of the 4-amino group.
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The nonpteridine moiety of the metabolite of MTX is identical with the nonpteridine moiety of MTX.
5 .
Tlie structure 4-amino-4-deoxy-7-hydroxy-N1o-methylpteroylglutamic acid ( 7-hydroxy-MTX) is proposed for the MTX metabolite.
REFERENCES
(1) Johns, D.