Statistical analysis of CDR3 length distributions for the assessment of T and B cell repertoire biases
✍ Scribed by Patrick Miqueu; Marina Guillet; Nicolas Degauque; Jean-Christophe Doré; Jean-Paul Soulillou; Sophie Brouard
- Book ID
- 116755935
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 496 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0161-5890
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## Abstract The third complementarity‐determining region (CDR) of the TCR α and β chains forms loops that engage amino acid residues of peptides complexed with MHC. This interaction is central to the specific discrimination of antigenic‐peptide–MHC complexes by the TCR. The TCRβ chain CDR3 loop is