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Statin inhibits hypoxia-induced endothelin-1 via accelerated degradation of HIF-1 in vascular smooth muscle cells

โœ Scribed by Hisada, T.; Ayaori, M.; Ohrui, N.; Nakashima, H.; Nakaya, K.; Uto-Kondo, H.; Yakushiji, E.; Takiguchi, S.; Terao, Y.; Miyamoto, Y.; Adachi, T.; Nakamura, H.; Ohsuzu, F.; Ikewaki, K.; Sakurai, Y.


Book ID
115458325
Publisher
Oxford University Press
Year
2012
Tongue
English
Weight
351 KB
Volume
95
Category
Article
ISSN
0008-6363

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## Abstract The migration of vascular smooth muscle cells from the media to intima and their subsequent proliferation are critical causes of arterial wall thickening. In atherosclerotic lesions increases in the thickness of the vascular wall and the impairment of oxygen diffusion capacity result in