✦ LIBER ✦

State of the art in restless legs syndrome therapy: Practice recommendations for treating restless legs syndrome

✍ Scribed by Wolfgang H. Oertel; Claudia Trenkwalder; Marco Zucconi; Heike Benes; Diego Garcia Borreguero; Claudio Bassetti; Markku Partinen; Luigi Ferini-Strambi; Karin Stiasny-Kolster

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 115 KB
Volume: 22
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.21545

No coin nor oath required. For personal study only.

✦ Synopsis

Dopaminergic agents are the best-studied agents and are considered first-line treatment of restless legs syndrome (RLS). Extensive data are available for levodopa, pramipexole, and ropinirole, which have approval for the indication RLS, and to a smaller extent for cabergoline, pergolide, and rotigotine. Apart from one recent study, comparing two active drugs (levodopa and cabergoline), no comparative studies have been published. The individual treatment regimen with the most appropriate agent concerning efficacy and side effects has to be selected by the treating physician. On the basis of these clinical trials and expert opinion of the authors, a treatment algorithm is proposed to support the search for the optimal individual treatment. Opioids and anticonvulsants such as gabapentine are second-line options in individual patients. Iron substitution is justified in people with iron deficiency related RLS (ferritin concentration lower than 50 g/L).

📜 SIMILAR VOLUMES

The role of iron in restless legs syndro

The role of iron in restless legs syndrome

✍ Richard P. Allen; Christopher J. Earley 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 230 KB 👁 1 views

The impressive relief from restless legs syndrome (RLS) symptoms provided by levodopa treatment indicates RLS is caused by a dopaminergic abnormality. But similar and more lasting relief also occurs for iron treatment in some patients. Thus there are two major putative causes for RLS: CNS dopaminerg

Genetics of restless legs syndrome (RLS)

Genetics of restless legs syndrome (RLS): State-of-the-art and future directions

✍ Juliane Winkelmann; Oli Polo; Federica Provini; Sonja Nevsimalova; David Kemlink 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 95 KB

Several studies demonstrated that 60% of restless legs syndrome (RLS) patients have a positive family history and it has been suggested that RLS is a highly hereditary trait. To date, several loci have been mapped but no gene has been identified yet. Phenocopies and possible nonpenetrants made it di

Clinical trials in restless legs syndrom

Clinical trials in restless legs syndrome—Recommendations of the European RLS Study Group (EURLSSG)

✍ Claudia Trenkwalder; Ralf Kohnen; Richard P. Allen; Heike Benes̆; Luigi Ferini-S 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 90 KB 👁 1 views

The European Restless Legs Syndrome (RLS) Study Group (EURLSSG) is an association of European RLS experts who are actively involved in RLS research. A major aim of the Study Group is the development and continuous improvement of standards for diagnosis and treatment of RLS. Several members developed

Assessment of restless legs syndrome—Met

Assessment of restless legs syndrome—Methodological approaches for use in practice and clinical trials

✍ Ralf Kohnen; Richard P. Allen; Heike Benes; Diego Garcia-Borreguero; Wayne A. He 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 93 KB

The Restless Legs Syndrome (RLS) is a sensorimotor disorder that has only recently been extensively investigated by validated methods. Following the first presentation of diagnostic criteria by the International RLS Study Group in 1995, several methods were specifically developed for clinical trials

Cerebral generators involved in the path

Cerebral generators involved in the pathogenesis of the restless legs syndrome

✍ Dr Stefan F. Bucher; Klaus C. Seelos; Wolfgang H. Oertel; Maximilian Reiser; Cla 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 896 KB

Electrophysiological pattern of involunt

Electrophysiological pattern of involuntary limb movements in the restless legs syndrome

✍ Claudia Trenkwalder; Stefan F. Bucher; Wolfgang H. Oertel 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 605 KB

Patients with restless legs syndrome (RLS) suffer from involuntary limb movements during the day. We studied these leg movements in 18 idiopathic (n = 8) and uremic (n = 10) patients at rest. Electromyographically measured muscle contractions were preceded by sensory discomfort in all patients. The