State duration models in clinical and observational studies

✍ Scribed by J. F. Lawless; D. Y. T. Fong

• Book ID: 101238692
• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 126 KB
• Volume: 18
• Category: Article
• ISSN: 0277-6715
• DOI: 10.1002/(sici)1097-0258(19990915/30)18:17/18<2365::aid-sim262>3.0.co;2-q

✦ Synopsis

Many studies in medicine involve conditions whereby subjects make transitions among a set of de"ned states over time. In such situations the durations of sojourns in speci"c states is frequently of interest. This article considers the modelling and analysis of sojourn times, beginning with semi-Markov models in which the durations of di!erent sojourns are independent, and then considering extended models incorporating chronological time e!ects and random e!ects. Methodologic challenges for inference are discussed, and examples involving a relapse-remitting process and recurrent events are considered.