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State-dependent learning effects with a combination of alcohol and nicotine

โœ Scribed by G. Lowe

Publisher
Springer
Year
1986
Tongue
English
Weight
325 KB
Volume
89
Category
Article
ISSN
0033-3158

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โœฆ Synopsis

An experiment was carried out to investigate whether nicotine ingestion (via cigarette smoking) interacted with alcohol (vodka and tonic) in its effect on statedependent learning (SDL) in humans. On Day I of the 2-day experiment 24 subjects were required to learn a simple route map previously found to be SDL sensitive with alcohol. All subjects ingested 0.66 g alcohol/kg body wt. and smoked two medium tar cigarettes (average nicotine content 1.4 rag). Twenty-four hours later, subjects attempted recall under one of the following drug states; (i) alcohol and nicotine (A + N); (ii) alcohol and smoking placebo (A + O); (iii) Nicotine and placebo drink (O + N); and (iv) no drugs (O + O). Highest recall scores were observed in the A + N subjects, with O + N and O + O subjects recalling the least. A + O subjects had intermediate recall performance. Thus the combination did produce a clear SDL effect, with alcohol possibly contributing the major influence.

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