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Stat6 cooperates with Sp1 in controlling breast cancer cell proliferation by modulating the expression of p21Cip1/WAF1and p27Kip1

โœ Scribed by Wei, Min; Liu, Bingya; Gu, Qinlong; Su, Liping; Yu, Yingyan; Zhu, Zhenggang

Book ID
120184694
Publisher
Springer Netherlands
Year
2012
Tongue
English
Weight
714 KB
Volume
36
Category
Article
ISSN
1570-5870

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Estrogen regulated expression of the p21
Estrogen regulated expression of the p21Waf1/Cip1 gene in estrogen receptor positive human breast cancer cells
โœ Soma Mandal; James R. Davie ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 183 KB

## Abstract The cyclinโ€dependent kinase inhibitor protein p21^Waf1/Cip1^ is a potent tumor suppressor. Here, we demonstrate that estradiol regulates the p21^Waf1/Cip1^ gene. Estradiol induces p21^Waf1/Cip1^ mRNA expression within 30โ€“60โ€‰min independent of new protein synthesis in the estrogen recept