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Stat3 and the Inflammation/Acute Phase Response in Involution and Breast Cancer

✍ Scribed by Sara Pensa; Christine J. Watson; Valeria Poli

Publisher
Springer US
Year
2009
Tongue
English
Weight
572 KB
Volume
14
Category
Article
ISSN
1083-3021

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πŸ“œ SIMILAR VOLUMES

Stat3 and the Inflammation/Acute Phase R
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✍ Sara Pensa; Christine J. Watson; Valeria Poli πŸ“‚ Article πŸ“… 2009 πŸ› Springer US 🌐 English βš– 572 KB

The transcription factor Stat3 is essential for timely initiation of post-lactational regression and orchestrates the processes of cell death and tissue remodelling that occur during the first 6 days of involution in the mouse. Paradoxically, STAT3 is also frequently found to be constitutively activ

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## Abstract Akt signaling may promote breast cancer progression and poor disease outcome. We hypothesized that serum insulin‐like growth factor I (IGF‐I) and a proinflammatory tumor environment induce phosphorylation of Akt and downstream targets of Akt in breast cancer. We studied the relationship