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STAT1-independent inhibition of cyclooxygenase-2 expression by IFNγ; a common pathway of IFNγ-mediated gene repression but not gene activation

✍ Scribed by Klampfer, L; Huang, J; Kaler, P; Sasazuki, T; Shirasawa, S; Augenlicht, L


Book ID
110072021
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
388 KB
Volume
26
Category
Article
ISSN
0950-9232

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## Abstract β‐Site APP cleaving enzyme 1 (BACE1) is an essential enzyme for the production of β amyloid. Since we found that injection of interferon‐γ (IFN‐γ) into young mouse brains increased BACE1 expression in astrocytes, we investigated molecular mechanisms underlying this process by cloning a