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Starch paste granulations: Binder dilution effects on granulations and tablets

โœ Scribed by Philip M. Hill


Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
188 KB
Volume
65
Category
Article
ISSN
0022-3549

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Starch paste granulations: Factors causi
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2.0 2.5 3.0 3.5 4.0 COMPRESSION LOAD, Ib X lo-' Figure %-Tablet hardness-compression load profiles and corresponding disintegration times. Miring time was 5 min. Key: o and A, tablet hardness; and 0 and A, tablet disintegration time.

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The objective is to provide mechanistic understanding of a preferred wet granulation process that a binder is added in a dry state. Blends of CaCO(3) and binders were prepared and used as model systems, and they were exposed to either 96% RH (rubbery/solution state) or 60% RH (glassy state) at room