Staphylococcus aureus α-toxin. 2. Reduction of epidermal growth factor receptor affinity in PC12 cells
✍ Scribed by Philip Lazarovici; Kai-Foon Jesse Chan
- Book ID
- 119006848
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 785 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0041-0101
No coin nor oath required. For personal study only.
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Lysophosphatidic acid (LPA) is a lipid metabolite that induces the activation of mitogen-activated protein kinase (MAPK) through binding to the G protein-coupled receptor in a number of cell lines and cultures. Recent studies have revealed that LPA is able to rapidly induce the phosphorylation of MA
Mutant PC12 cell clones (PC84 cells) were obtained by transfection with nerve growth factor (NGF) cDNA. These cells secreted active NGF, extended short processes, and proliferated faster than the parental PC12 cells. These features are of great interest because the parental PC12 cells cease prolifer