Flow cytometric methods for measurement of low-density lipoprotein (LDL) receptor activity on peripheral blood mononuclear cells (PBMC) may be used to identify patients with familial hypercholesterolemia (FH). However, cellular LDL receptor activities measured in FH heterozygotes may overlap with th
Standardization of a flow cytometric method for measurement of low-density lipoprotein receptor activity on blood mononuclear cells
✍ Scribed by Kari Løhne; Petter Urdal; Trond P. Leren; Serena Tonstad; Leiv Ose
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 607 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0196-4763
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We have evaluated whether low density lipoprotein (LDL) receptor activity of stimulated lymphocytes, as measured by an improved flow cytometric assay, may be used to diagnose familial hypercholesterolemia (FH). Cells were isolated from 75 children suspected from strict clinical criteria to be FH het
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