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Standard and low-dose chemotherapy for the treatment of myelodysplastic syndromes

โœ Scribed by Bruce D Cheson

Book ID
114119449
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
64 KB
Volume
22
Category
Article
ISSN
0145-2126

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Treatment of myelodysplastic syndromes with low-dose oral 6-thioguanine
โœ Spitzer, Thomas R. ;Lazarus, Hillard M. ;Crum, Edward D. ;Weisman, Russell ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 374 KB

Several cytotoxic agents when used in vitro in very low concentrations have been shown to induce differentiation of leukemic cells. We treated 18 patients with rnyelodysplastic syndromes with lowdose oral 6-thioguanine (6-TG; 20 to 60 rng daily). Four patients demonstrated significant improvement in