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Staging of α-synuclein in the olfactory bulb in a model of Parkinson's disease: Cell types involved

✍ Scribed by Isabel Ubeda-Bañon; Daniel Saiz-Sanchez; Carlos de la Rosa-Prieto; Alicia Mohedano-Moriano; Noelia Fradejas; Soledad Calvo; Lucia Argandoña-Palacios; Susana Garcia-Muñozguren; Alino Martinez-Marcos

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
577 KB
Volume
25
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

Impaired olfaction is an early symptom of Parkinson's disease. The underlying neuropathology likely includes α‐synucleinopathy in the olfactory bulb at an earlier stage (Braak's stage1) than pathology in the substantia nigra, which is not observed until stage 3. In this report, we investigated the distribution and cell types affected by α‐synuclein in the olfactory bulb of transgenic mice (2–8 months of age) expressing the human A53T variant of α‐synuclein. α‐Synuclein immunostaining progressively affects interneurons and mitral cells. Double labeling studies demonstrate that dopaminergic cells are hardly involved, whereas glutamatergic‐ and calcium binding protein‐positive cells are severely affected. This temporal evolution and the cell types expressing α‐synuclein are reminiscent of idiopathic Parkinson's disease and support the usefulness of this model to address specific topics in the premotor phase of the disease. © 2010 Movement Disorder Society

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