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Stacking interactions between aromatic amino acids and adenine ring of ATP in zinc mediated ternary complexes

✍ Scribed by Jean-Jacques Toulme

Publisher: Elsevier Science
Year: 1978
Weight: 703 KB
Volume: 8
Category: Article
ISSN: 0006-3061
DOI: 10.1016/s0006-3061(00)80165-9

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✦ Synopsis

Spectrophotometrlc studies have provided evidence for zinc-mediated ternary complexes between ATP and aromatic ammo acids. The hypochromicity observed in the 260 nm hand of ATP increased in the order phenyl-&nine < tyroslnn < tryptophan. Adding alanlne did not produce any change of the ATP spectrum. The association constant was four fold higher for the ATP-Zinc-Tryptophan complex than for that of the ATP-Zinc-Alanme. The increased stability of the former complex was ascribed to the stacking interaction between indole and adenine rings. The ma&num concentration of the ATP-ZlnoTryptophan complex occurred at about pH 8.0. For these ternary complexes several possible stacked structures Involving or not involving N(7) of adenine are discussed_ ' The expression '*increase" and "decrease" for absorbance variations refers to absolute VdUeS.

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