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Stable therapeutic serum levels of human alpha-1 antitrypsin (AAT) after portal vein injection of recombinant adeno-associated virus (rAAV) vectors

✍ Scribed by Song, S; Embury, J; Laipis, P J; Berns, K I; Crawford, J M; Flotte, T R

Book ID
110038902
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
468 KB
Volume
8
Category
Article
ISSN
0969-7128

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## Abstract Alpha 1 antitrypsin (AAT) is a serine proteinase inhibitor (serpin). One well‐known function of this protein is to inactivate neutrophil elastase and other neutrophil‐derived proteinases, and prevent the destruction of pulmonary extracellular matrix. Deficiency of AAT can cause emphysem