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Stable T cell–dendritic cell interactions precede the development of both tolerance and immunity in vivo

✍ Scribed by Shakhar, Guy; Lindquist, Randall L; Skokos, Dimitris; Dudziak, Diana; Huang, Julie H; Nussenzweig, Michel C; Dustin, Michael L

Book ID
109923118
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
578 KB
Volume
6
Category
Article
ISSN
1529-2908

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## Abstract Steady‐state dendritic cells (DC) present peptide‐MHC complexes to T cells in a tolerogenic manner, presumably because of deficient costimulation. However, it is clear that the path to tolerance involves initial T cell activation, suggesting that the deficit may lie in late‐acting costi