Stable RNA interference (RNAi) as an option for anti-bcr-abl therapy

Gene therapy for BCR-ABL+ human CML with

Gene therapy for BCR-ABL+ human CML with dual phosphorylation resistant p27Kip1 and stable RNA interference using an EBV vector

✍ Amitava Sengupta; Debasish Banerjee; Sarmila Chandra; Subrata Banerjee 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 715 KB

## Abstract ## Background BCR‐ABL‐mediated chronic myelogenous leukemia (CML) CD34^+^ cell proliferation mostly depends on the nucleo‐cytoplasmic ratio of the cyclin‐dependent kinase inhibitor p27. The ubiquitin‐ligase SCF^Skp2^ promotes degradation of phosphorylated p27 at T187 in the nucleus, re