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Stable Response after Administration of Stem Cell Factor Combined with Granulocyte Colony-Stimulating Factor in Aplastic Anemia

✍ Scribed by Kensuke Usuki; Seiko Iki; Shunya Arai; Kimiko Iijima; Fumimaro Takaku; Akio Urabe

Book ID
111835489
Publisher
Carden Jennings Publishing
Year
2006
Tongue
English
Weight
206 KB
Volume
83
Category
Article
ISSN
0925-5710

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## Abstract Recombinant human granulocyte colony‐stimulating factor (rhG‐CSF) and erythropoietin (rhEPO) were used to treat patients with aplastic anemia (AA). In terms of effects on erythrocyte recovery, the combined use of rhG‐CSF and rhEPO showed a favorable response in 6 of 14 (42.9%) patients

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We have studied stromal cell function in naive or interleukin-1 (IL-1)-stimulated (100 pgiml) long-term marrow cultures (LTC) from 1 2 normal donors and 21 patients with severe aplastic anemia (AA). Conditioned media (CM) from normal LTC contained levels of erythroid burst-promoting activity (BPA) a