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Stable nimodipine tablets with high bioavailability containing NM-SD prepared by hot-melt extrusion

✍ Scribed by Fu Jijun; Zhang Lili; Guan Tingting; Tang Xing; He Haibing

Book ID
104089217
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
448 KB
Volume
204
Category
Article
ISSN
0032-5910

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✍ Fu Jijun; Xu Lishuang; Tao Xiaoguang; Su Min; Zhao Mingming; He Haibing; Tang Xi 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 141 KB 👁 1 views

Nimodipine (NM) solid dispersions (SD) were prepared by hot-melt extrusion with polyvinylpyrrolidone/vinyl acetate copolymer (PVP-VA; Kollidon VA64) as the carrier, then the extrudate was stored at different temperatures (20°C, 40°C, 60°C) after milling. Conventional differential scanning calorimetr