Stable gene expression from a mammalian artificial chromosome
โ Scribed by Grimes, B. R.
- Book ID
- 111744467
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 546 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1469-221X
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A mammalian artificial chromosome (MAC) may be assembled through the juxtapposition of three kinds of DNA elements: a centromere, several DNA replication origins, and two telomeric repeats. The resulting structure should be able to carry and express one or more selected genes (transgenes), introduce
## Abstract The introduction of mammalian artificial chromosomes (__AC__s) into zygotes represents an alternative, more predictive technology for the production of recombinant proteins in transgenic animals. The aim of these experiments was to examine the effects of artificial chromosome microinjec