Stable formyl peptide receptor agonists that activate the neutrophil NADPH-oxidase identified through screening of a compound library

The two neutrophil members of the formyl

The two neutrophil members of the formylpeptide receptor family activate the NADPH-oxidase through signals that differ in sensitivity to a gelsolin derived phosphoinositide-binding peptide

✍ Huamei Fu; Lena Björkman; Paul Janmey; Anna Karlsson; Jennie Karlsson; Charlotta 📂 Article 📅 2004 🏛 BioMed Central 🌐 English ⚖ 311 KB

## Background The formylpeptide receptor family members FPR and FPRL1, expressed in myeloid phagocytes, belong to the G-protein coupled seven transmembrane receptor family (GPCRs). They share a high degree of sequence similarity, particularly in the cytoplasmic domains involved in intracellular sig