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Stable expression of human CYP2E1 in chinese hamster cells: high sensitivity to N,N-dimethylnitrosamine in cytotoxicity testing

โœ Scribed by Tetsuya Nakagawa; Minoru Sawada; Frank J Gonzalez; Tsuyoshi Yokoi; Tetsuya Kamataki

Book ID
114133246
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
515 KB
Volume
360
Category
Article
ISSN
0165-1161

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## Abstract Heterocyclic amine carcinogens such as 2โ€aminoโ€1โ€methylโ€6โ€phenylimidazo [4,5โ€b] pyridine (PhIP) are present in diet and cigarette smoke. Bioactivation in humans includes Nโ€hydroxylation catalyzed by cytochrome P4501A2 possibly followed by Oโ€acetylation catalyzed by Nโ€acetyltransferase 2