Stable Aqueous Dispersion of PEGylated Nanoparticles by Polyelectrolyte Complex Formation

✍ Scribed by Dilyana Paneva; Laetitia Mespouille; François Bougard; Nevena Manolova; Philippe Degée; Iliya Rashkov; Philippe Dubois

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 201 KB
• Volume: 28
• Category: Article
• ISSN: 1022-1336
• DOI: 10.1002/marc.200700079

✦ Synopsis

Abstract

Stable aqueous dispersions of nanoparticles were prepared by polyelectrolyte complex formation between well‐defined poly(ethylene glycol)‐block‐poly(2‐acrylamido‐2‐methyl‐1‐propane sodium sulfonate) and poly(ethylene glycol)‐block‐poly[2‐(dimethylamino)ethyl methacrylate] diblock copolymers. Controlled synthesis of the copolymers was achieved by water‐based atom transfer radical polymerization (ATRP). The nanoparticles were characterized by a quite narrow and monomodal size distribution as evidenced by dynamic light scattering (DLS) and confirmed by atomic force microscopy (AFM) after solution casting and freeze‐drying.

magnified image