Stabilization of ubiquitous mitochondrial creatine kinase preprotein by APP family proteins

Hodgkin disease-derived cell lines expre

Hodgkin disease-derived cell lines expressing ubiquitous mitochondrial creatine kinase show growth inhibition by cyclocreatine treatment independent of apoptosis

✍ Martin Kornacker; Uwe Schlattner; Theo Wallimann; Micheal R. Verneris; Robert S. 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 155 KB

Ubiquitous mitochondrial creatine kinase (uMtCK), a key enzyme in energy metabolism, was identified by differential display PCR to be specifically overexpressed in L1236, the first cell line of definite Hodgkin origin. RT-PCR confirmed overexpression of uMtCK in the L1236 cell line and the absence o