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Stabilization of the Tertiary Structure of the Cholera Toxin A1 Subunit Inhibits Toxin Dislocation and Cellular Intoxication

โœ Scribed by Shane Massey; Tuhina Banerjee; Abhay H. Pande; Michael Taylor; Suren A. Tatulian; Ken Teter

Book ID
116664280
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
980 KB
Volume
393
Category
Article
ISSN
0022-2836

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Cautionary note on the use of the B subunit of cholera toxin as a ganglioside GM1 probe: Detection of cholera toxin A subunit in B subunit preparations by a sensitive adenylate cyclase assay
โœ Sarah Spiegel ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 591 KB

The use of the B subunit of cholera toxin, a protein that binds specifically to ganglioside GM 1, has provided a new paradigm for studying physiological functions of ganglioside GMl . The B subunit inhibited the growth of rat glioma C6 cells that had been pretreated with ganglioside GM1. In some pre