## Abstract Triplex‐forming oligonucleotides (TFOs) containing 9‐deazaguanine __N__^7^‐(2′‐deoxyribonucleoside) **1a** and halogenated derivatives **1b,c** were synthesized employing solid‐phase oligonucleotide synthesis. For that purpose, the phosphoramidite building blocks **5a**–**c** and **8a**
✦ LIBER ✦
Stabilization of tandem dG–dA base pairs in DNA-hairpins: replacement of the canonical bases by 7-deaza-7-propynylpurines
✍ Scribed by Seela, Frank; Budow, Simone; Shaikh, Khalil I.; Jawalekar, Anup M.
- Book ID
- 119960476
- Publisher
- Royal Society of Chemistry
- Year
- 2005
- Tongue
- English
- Weight
- 200 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1477-0520
- DOI
- 10.1039/B510444K
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## Abstract Nucleobase‐directed spin‐labeling by the azide‐alkyne ‘click’ (CuAAC) reaction has been performed for the first time with oligonucleotides. 7‐Deaza‐7‐ethynyl‐2′‐deoxyadenosine (**1**) and 5‐ethynyl‐2′‐deoxyuridine (**2**) were chosen to incorporate terminal triple bonds into DNA. Oligon