Stabilization of homatropine methylbromide-iodobismuthate complex in solution for quantitative analysis of homatropine methylbromide

✍ Scribed by S. Ahuja; D. Spiegel; F. R. Brofazi

• Publisher: John Wiley and Sons
• Year: 1970
• Tongue: English
• Weight: 234 KB
• Volume: 59
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600590334

✦ Synopsis

The colorimetric reaction between homatropine methylbromide (HMB) and the Dragendorff reagent was investigated as a means of quantitative analysis for HMB. The reaction was found to be unstable under normal laboratory lighting conditions. Stabilization of the colorimetric reaction was achieved by the addition of methanol to an acetone solution of the HMBiodobismuthate complex in the ratio of 1 : 1. The stabilization was accompanied by a hypsochromic shift from 474 to 382 mp. The stabilized colorimetric reaction follows the Beer-Lambert law in the range of concentrations of HMB studied for this investigation. The sensitivity of the method was found to be 0.1 mg. of HMB under the experimental conditions described. However, with slight modifications. this method should be useful for much smaller concentrations of HMB.

Keyphrases 0 Homatropine methylbromide analysis-reaction mechanism 0 Iodobismuthate complex stabilization-homatropine methylbromide analysis 0 Colorimetric reaction-stabilization (7)