## Abstract ## Background The potential of lentiviral vectors for clinical gene therapy has not yet been evaluated. One of the reasons is the cytotoxicity of lentiviral packaging genes which makes the generation of stable producer cell lines difficult. Therefore, a novel packaging system for lenti
Stabilization of gammaretroviral and lentiviral vectors: from production to gene transfer
β Scribed by Marlene Carmo; Ana Alves; Ana Filipa Rodrigues; Ana Sofia Coroadinha; Manuel Jose Teixeira Carrondo; Paula Marques Alves; Pedro Estilita Cruz
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 328 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1099-498X
- DOI
- 10.1002/jgm.1353
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract ## Background We wanted to investigate the ability of recombinant equine infectious anemia virus (EIAV) vectors to transduce photoreceptor cells by developing a series of photoreceptorβspecific promoters that drive strong gene expression in photoreceptor cells. ## Methods Promoter fr
## Abstract Viral vectorβmediated overexpression of neurotrophins in cells constituting the neural scar may represent a powerful approach to rendering scar tissue of a central nervous system (CNS) lesion permissive for neuronal regrowth. In this study a lentiviral vector encoding green fluorescent
## Abstract ## Background The loss of gene transfer capacity in retroviral vectors constitutes a major disadvantage in the development of retroviral vectors for gene therapy applications. In the present work the loss of a vector's capacity to perform reverse transcription was studied as a possible