Stabilization of G-Quadruplex DNA with Platinum(II) Schiff Base Complexes: Luminescent Probe and Down-Regulation of c-myc Oncogene Expression

✍ Scribed by Peng Wu; Dik-Lung Ma; Chung-Hang Leung; Siu-Cheong Yan; Nianyong Zhu; R. Abagyan; Chi-Ming Che

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 863 KB
• Volume: 15
• Category: Article
• ISSN: 0947-6539
• DOI: 10.1002/chem.200901943

✦ Synopsis

298 350 (1.0), 425 (2.0), 464 (2.8), 493 (3.5) 596 (7.5; 0.21) CH 2 Cl 298 345A C H T U N G T R E N N U N G (0.8), 425 (2.0), 463 (2.7), 493 (3.

5. 596 (6.9; 0.20) MeCN 298 340 (0.9), 419 (2.1), 458 (2.9), 487 (3.5) 595 (6.6; 0.13) 2 a C 6 H 6 298 288 (1.4), 364 (3.2), 380 (1.7, sh), 488 (0.01, sh) 543 (3.3; 0.16) CH 2 Cl 298 285 (1.2), 359 (2.9), 382 (1.6, sh), 486 (0.01, sh) 542 (3.1; 0.15) MeCN 298 285 (0.8), 347 (3.0), 388 (0.95, sh), 478 (0.01, sh) 536 (3.1; 0.13) MeOH/CH 2 Cl 2 (10:1) 298 282 (0.75), 345 (3.1), 395 (1.0, sh), 478 (0.01, sh) 535 (3.0; 0.13) 2 b C 6 H 6 298 345 (0.6, sh), 373 (1.1), 406 (0.4), 485 (0.01, sh) 531 (8.1; 0.32) CH 2 Cl 298 343 (0.6), 367 (1.1), 399 (0.5, sh), 487 (0.01, sh) 523 (8.0; 0.30) MeCN 298 340 (0.6, sh), 361 (1.0), 395 (0.7, sh), 488 (0.01, sh) 522 (7.6; 0.25) MeOH 298 339 (0.6), 363 (0.82), 394 (0.5, sh), 485 (0.01, sh) 521 (6.9; 0.22) 2 c C 6 H 6 298 306 (0.4), 322 (0.40, sh), 426 (0.24), 488 (0.03) 576 (6.2; 0.08) CH 2 Cl 298 304 (0.4), 315 (0.4, sh), 424 (0.23), 486 (0.02) 575 (6.1; 0.08) MeCN 298 304 (0.4), 310 (0.4, sh), 421 (0.21), 485 (0.02) 571 (6.0; 0.08) MeOH/CH 2 Cl 2 (10:1) 298 295 (0.4), 309 (04, sh), 417 (0.28), 485 (0.01) 568 (6.0; 0.07) 2 d C 6 H 6 298 287 (1.5), 341 (0.43, sh), 427 (0.22), 489 (0.02) 577 (6.2; 0.08) CH 2 Cl 298 280 (1.7), 341 (0.51, sh), 426 (0.31), 489 (0.02) 576 (6.0; 0.08) MeCN 298 277 (1.7), 338 (0.52, sh), 421 (0.30), 488 (0.03) 574 (4.7; 0.07) MeOH/CH 2 Cl 2 (10:1) 298 275 (1.1), 332 (0.38, sh), 417 (0.23), 488 (0.03) 573 (4.2, 0.07) 3