Nitroglycerin sublingual tablets were studied over a l-year period to determine tablet stability in terms of loss of strength, uniformity of tablets, and degradation of the drug itself. Tablets from six different firms were analyzed by a semiautomated procedure. The samples included two molded tablets and four compressed tablets, ranging in age at the time of initial assay from 40 days to over 1 year. The results indicated that there is a loss of strength of nitroglycerin tablets and that refrigeration slows down this loss. The study also indicated that these tablets were stable during the year of testing in terms of tablet uniformity and degradation of nitroglycerin.
Keyphrases 0 Nitroglycerin sublingual tablets-stability study, loss of strength, uniformity of tablets, and degradation of drug Tablets, sublingual nitroglycerin-stability Content uniformity-nitroglycerin sublingual tablets Stability-nitroglycerin sublingual tablets, loss of strength, uniformity of tablets, and degradhtion of drug Much recent research has been devoted to the tableting, packaging, storage, and analysis of sublingual nitroglycerin tablets. In 1973, Fusari (1) reported that tablets that were uniform when manufactured developed increased individual tablet variation upon storage because of the volatilization and subsequent intertablet migration of nitroglycerin. It has been reported (1-3) that packing materials, such as cotton and rayon, in contact with nitroglycerin tablets absorb varying amounts of nitroglycerin.
In light of all that has been reported about the problems of packaging and storage of sublingual nitroglycerin, a study was carried out to determine the stability of sublingual nitroglycerin in tablets in L \ 4 I. 3 6 MONTHS 12