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Stability of α-L-aspartyl-L-phenylalanine methyl ester hydrochloride in aqueous solutions

✍ Scribed by Prudel, M. ;Davíadková, E.

Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
271 KB
Volume
25
Category
Article
ISSN
0027-769X

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✦ Synopsis

Abstract

The stability of USAL (α‐L‐aspartyl‐L‐phenylalanine methyl ester hydrochloride) was studied in solutions in relation to the pH value (1.10–6.95 at 20 °C), the temperature (20–80 °C at pH 2.2) and the ionic strength (0.16–2.0 at 20 °C and pH 4.0). The effects of pH and temperature of the medium were very significant. From the point of view of the stability the optimum pH value lies in the pH range 2.5–4.5 and at lower temperature. The ionic strength did not affect the stability in the tested range. The effects of citric acid (0–10%) and sucrose (0–75%) were also investigated. An addition of citric acid exhibited an effect on USAL stability corresponding to the shift of pH value that it caused. The occurrence of sucrose in the solution had a favorable effect at higher concentrations.

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