✍ Scribed by Taub, Abraham ;Lieberman, Herbert
No coin nor oath required. For personal study only.
Stability of Vitamin B,,-Folk Acid Parenteral Solutions*
By ABRAHAM TAUBt and HERBERT LIEBERMAN1
The low solubility of folic acid in water, exce t at a relatively high pH, has prevented its use in parenteral solutions in com%ination with vitamin BIZ (cyanocobdamin), which attains optimum stability in thepH range 4 to 6.5. The present study utilizes selected solubilizers for folic acid, including aminoacetic acid, methyl glucamine, and niacinamide within a p H ran e of 6 to 6.5. Results indicate that niacinamide is the best of the solubilizers stuged. By special processing it is possible to dissolve and maintain in solution 5 mg. of folic acid per cc. at PH 6 under conditions compatible with crystalline vitamin BIZ at a concentration of 30 pg. per cc. Solutions show no significant loss of potency of either the folic acid or the viiamin BIZ after storage at room temperature and under accelerated conditions, and display satisfactory stability with respect to clarity of solution.
📜 SIMILAR VOLUMES
Using homocysteine as a functional marker, we determined optimal folic acid, vitamin B 12 , and vitamin B 6 dosages in 21 pediatric sickle cell disease (SCD) patients (11 HbSS, 10 HbSC;(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). Daily supplements of folic acid (400, 700, or 1,000 lg), vitamin B 12 (1, 3,